The University presently operates two campuses in Buchanan County, Virginia. The Slate Creek campus was the initial campus and currently serves as the main campus for the second-year pharmacy students. The Slate Creek campus, which occupies the first floor of the Buchanan County Industrial Development Authority facility, provides 12,674 square feet of space; can accommodate over 150 students; and includes a large lecture hall, several small to medium-sized classrooms, a multipurpose laboratory facility, a library and learning resources center, faculty and student lounges, a faculty conference room, and faculty and administrative offices. Among the many donations that the University received was a historical high school building and campus in Oakwood, Virginia, approximately 18 miles from the Slate Creek campus. This 1940 building has been renovated and currently serves as the flagship campus for the University and the main campus for first-year pharmacy students. It is a two-story structure spanning approximately 25,000 square feet, and it contains a large lecture hall, library, pharmaceutics laboratory, faculty research laboratory, conference room, faculty and student lounges, and faculty and administrative offices.

The University continues fundraising efforts to establish scholarships, endowments, and credibility with the academic community as well as with accrediting agencies. Fundraising is presently underway to construct and furnish a new building on the campus at Oakwood, which will allow for one college of pharmacy campus and afford sufficient space for future growth. Construction on the new building began in January 2008 with a projected timeline for completion of 12–18 months. The new facility will provide approximately 30,000 square feet housed in three stories and will become the center of educational activities. Architecturally, it will complement the existing historical building on campus. In addition to lecture halls, classrooms, lounges, and offices, this facility will have a state of the art "mock" pharmacy and patient simulation laboratory.

The University has entered into several collaborative agreements with established undergraduate programs in Central Appalachia to broaden educational opportunities and to increase the pool of quality student applicants from the region. In addition to the rigors of course work within the accelerated pharmacy curriculum, community service has been and remains a focus for the university. All students have an early and ongoing exposure to volunteerism through the Pharmacists in Community Service (PICS) program, whereby each student must complete fifty hours of community service per year in order to fulfill graduation requirements.

The history of the University of Appalachia throughout its brief five year existence has laid the groundwork for growth and quality. Future growth will focus on completing construction of the new facility and expanding our educational, research, scholarship, and community outreach initiatives and capabilities.

The University of Appalachia College of Pharmacy is strategically positioned in Buchanan County, Virginia, which shares borders with Kentucky and West Virginia in the center of the Appalachian coalfields. Central Appalachia faces significant economic and educational hurdles as well as health challenges. A recent report to the Virginia Legislature documented that residents of Southwest Virginia have difficulty obtaining and paying for health care, including dental and pharmaceutical care. The age-adjusted mortality rate in Southwest Virginia is 42% higher than the age-adjusted death rate for Virginia as a whole. When compared with the entire population of Virginia, residents of Southwest Virginia are 26% more likely to die from heart disease, 44% more likely to die from chronic obstructive pulmonary disease, 54% more likely to die from pneumonia or influenza, 28% more likely to die from diabetes, 55% more likely to die from chronic liver disease and cirrhosis, and 67% more likely to commit suicide. By bringing higher education and advances in health care to the region, the University is well positioned to be a catalyst for positive changes in economic development, education, and health.

The University was created to serve regional needs and to provide a model for progressive pharmacy practice and education in context with rural health care. The college of pharmacy will help address the health needs of Central Appalachia through pharmacy education, scholarship, and service.